4-Acetamido Antipyrine (Synonyms: 4-AAAP,NSC 331807) |
| カタログ番号GC91680 |
4-Acetamido antipyrine (4-AAAP) is an active metabolite of the non-opioid analgesic and antipyretic prodrug metamizole .
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Cas No.: 83-15-8
Sample solution is provided at 25 µL, 10mM.
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4-Acetamido antipyrine (4-AAAP) is an active metabolite of the non-opioid analgesic and antipyretic prodrug metamizole .[1] It inhibits β-galactosidase activity, a marker of liver X receptor α (LXRα) activity, in a yeast two-hybrid assay (IC20 = 79.9 µM).[2] 4-AAAP has been found as a micropollutant in reclaimed wastewater.
References:
[1].Kipka, H., Tomasi, R., Hübner, M., et al.Simultaneous LC-ESI-MS/MS quantification of levosimendan and its metabolites for therapeutic drug monitoring of cardiac surgery patientsPharmaceutics14(7)1454(2022).
[2].Zhang, H., Jia, Y., Tang, Z., et al.Screening of chemicals with binding activities of liver X receptors from reclaimed watersSci. Total Environ.713:136570(2020).
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