4'-O-methyl Quercetin (Synonyms: 4'-methoxy Quercetin, Tamarixetin) |
| カタログ番号GC41003 |
4'-O-メチル ケルセチン (4'-O-メチル ケルセチン) は、ケルセチンの天然フラボノイド誘導体で、抗酸化作用と抗炎症作用があります。
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Cas No.: 603-61-2
Sample solution is provided at 25 µL, 10mM.
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4'-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4'-O-methyl Quercetin is a major metabolite of quercetin that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM. It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4'-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4'-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).
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