6-Aminochrysene (6-Chrysenamine) (Synonyms: 6-Aminochrysene, NSC 80186) |
カタログ番号GC31932 |
6-アミノクリセン (6-クリセナミン) (6-アミノクリセン (6-クリセナミン)) は、脾腫、骨髄性白血病、および乳癌の治療において化学療法剤として使用される芳香族アミンです。
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Cas No.: 2642-98-0
Sample solution is provided at 25 µL, 10mM.
6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer.
6-Aminochrysene inhibits the hydroxylation of aniline, 0-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. Pre-treatment of rats with 6-aminochrysene markedly decreases the N-demethylation in vitro but significantly increases the hydroxylation and the 0-demethylation[1].
6-Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer[1]. Long term topical skin application of 6-Aminochrysene to mice induces development of benign skin tumors after 3 months and of skin malignancies after 7 months. Female mice respond earlier than males. Induction of skin tumors is more rapid when 6-Aminochrysene is applied ventrally instead of dorsally. Urinary excretion is about twice as high after skin application than after oral administration[2].
[1]. Russo R, et al. Effects of 6-aminochrysene on liver microsomal enzyme activity. Xenobiotica. 1976 Apr;6(4):201-5. [2]. Lambelin G, et al. Carcinogenicity of 6-aminochrysene in mice. Eur J Cancer. 1975 May;11(5):327-34.
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