α-GalCer analog 8 (Synonyms: α-Galactosylceramide analog 8) |
| カタログ番号GC45206 |
α-ガラクトシルセラミドアナログ8（α-GalCerアナログ8）は、α-ガラクトシルセラミドのトリアゾール誘導体です。
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Cas No.: 922727-14-8
Sample solution is provided at 25 µL, 10mM.
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α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 µg per animal dose, indicating a Th2 response.
Reference:
[1]. Lee, T., Cho, M., Ko, S.-Y., et al. Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant α-GalCer. J. Med. Chem. 50(3), 585-589 (2007).
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