A11 (trifluoroacetate salt) (Synonyms: CPP-EYVQTVKSSKG) |
| カタログ番号GC91473 |
A11は、HIV-1 Tatタンパク質輸送ドメインと、アネキシンA1 N末端の残基20〜30に対応する11アミノ酸ペプチドが結合した細胞貫通ペプチドです。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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A11 is a cell-penetrating peptide composed of the HIV-1 Tat protein transduction domain linked to an 11-amino acid peptide corresponding to residues 20-30 of the annexin A1 N-terminus.1 It decreases annexin A1 binding to Eph receptor tyrosine kinase A2 (EphA2) and increases EphA2 ubiquitination in HK1 nasopharyngeal carcinoma (NPC) cells. A11 (10 µM) inhibits HK1 and 5-8F NPC cell proliferation, migration, and invasion. In vivo, A11 reduces tumor volume in 5-8F and HK1 NPC mouse xenograft models.
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Review for A11 (trifluoroacetate salt)
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