Acetyl Coenzyme A (sodium salt) (Synonyms: AcetylCoA) |
| カタログ番号GC42697 |
アセチル-コエンザイム A (アセチル-CoA) 三ナトリウムは、膜非透過性の中枢代謝中間体であり、TCA サイクルと酸化的リン酸化代謝に関与しています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 102029-73-2
Sample solution is provided at 25 µL, 10mM.
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Acetyl Coenzyme A (sodium salt) is an essential cofactor and acyl carrier in enzymatic acetyl transfer reactions[1]. Acetyl Coenzyme A can serve as an acetyl donor for histone acetylase (HAT) for post-translational acetylation of histones and non-histone proteins[2]. Acetyl Coenzyme A is formed by the oxidative decarboxylation of pyruvate in mitochondria, the oxidation of long-chain fatty acids, or the oxidative degradation of certain amino acids[3]. Acetyl Coenzyme A is the starting compound of the citric acid cycle (Kreb cycle), a key precursor for lipid biosynthesis, and the source of all fatty acid carbons[4]. Acetyl Coenzyme A positively regulates the activity of pyruvate carboxylase[5]. Acetyl Coenzyme A is a precursor of the neurotransmitter acetylcholine[6].
References:
[1] Masiarz F R. Acyl-coenzyme-a: Coenzyme-a Acyltransferase--a Novel Mammalian Enzyme[M]. University of Michigan, 1973.
[2] Takahashi H, McCaffery J M, Irizarry R A, et al. Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription[J]. Molecular cell, 2006, 23(2): 207-217.
[3] Abo Alrob O, Lopaschuk G D. Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation[J]. Biochemical Society Transactions, 2014, 42(4): 1043-1051.
[4] Kumar P, Dubey K K. Citric acid cycle regulation: Back bone for secondary metabolite production[M]//New and Future Developments in Microbial Biotechnology and Bioengineering. Elsevier, 2019: 165-181.
[5] Numa S, Tanabe T. Acetyl-coenzyme A carboxylase and its regulation[M]New comprehensive biochemistry. Elsevier, 1984, 7: 1-27.
[6] Szutowicz A, Bielarczyk H, Jankowska-Kulawy A, et al. Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases[J]. Neurochemical research, 2013, 38: 1523-1542.
| Cas No. | 102029-73-2 | SDF | |
| 同義語 | AcetylCoA | ||
| Canonical SMILES | O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Na].[Na].[Na] | ||
| Formula | C23H38N7O17P3S•3Na | M.Wt | 878.5 |
| 溶解度 | PBS (pH 7.2): 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.1383 mL | 5.6915 mL | 11.383 mL |
| 5 mM | 0.2277 mL | 1.1383 mL | 2.2766 mL |
| 10 mM | 0.1138 mL | 0.5692 mL | 1.1383 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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