ADS032 |
| カタログ番号GC71405 |
ADS032はNLRP 1とNLRP 3の二重抑制剤であり、炎症性小体の形成を迅速、可逆的、安定的に抑制することができる。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2757333-37-0
Sample solution is provided at 25 µL, 10mM.
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ADS032 is a dual inhibitor of NLRP1 and NLRP3 that can rapidly, reversibly and stably inhibit inflammasome formation. ADS032 can reduce NLPR1 and NLRP3 activation of human macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduce NLRP3-induced ASC speck formation. ADS032 protected mice against the deadly influenza A virus, reducing inflammation in the lungs and improving survival. ADS032 inhibits Nigericin -induced IL-1β secretion with IC50s of 94.6 μM (No wash out) and 354 μM (Wash out) respectively.
Review for ADS032
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for ADS032
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