AFP 07 (free acid) |
| カタログ番号GC42746 |
プロスタグランジンI2は不安定なプロスタノイドであり、IPプロスタノイド受容体を介して血小板凝集を抑制し、肺血管床の血管拡張を促進します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 788799-13-3
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin I2 is an unstable prostanoid which, through the 'I prostanoid' (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM). AFP 07 shows weaker affinity for EP receptors, with Ki values of > 100 nM for EP1-3 and > 10 nM for EP4. In piglet and rabbit saphenous veins, which express both IP and EP4, the EP4 antagonist AH 23848 reduces AFP 07-mediated relaxation, suggesting that AFP 07 activates EP4 as well as IP, particularly when both receptors are present.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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