Alendronic acid |
| カタログ番号GC39476 |
ビスフォスフォネートであるアレンドロン酸は、ファルネシル二リン酸シンターゼ（FDPS）阻害剤です。アレンドロン酸は、破骨細胞を介した骨吸収を阻害します。アレンドロン酸は、閉経後骨粗鬆症、悪性高カルシウム血症、パジェット病に効果を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66376-36-1
Sample solution is provided at 25 µL, 10mM.
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Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget's disease[1].
[1]. Teixeira S, et al. Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma. Pharmaceutics. 2020 Mar 24;12(3). pii: E293. [2]. Duckworth AD, et al. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. J Bone Miner Res. 2019 Jun;34(6):1025-1032.
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