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Ambroxol HCl (Synonyms: NA 872)

カタログ番号GC15458

アンブロキソール HCl (NA-872 塩酸塩) は、プロドラッグであるブロムヘキシンの活性代謝物であり、強力な去痰効果があります。

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Ambroxol HCl 化学構造

Cas No.: 23828-92-4

サイズ 価格 在庫数 個数
50mg
$38.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of Ambroxol HCl

AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.

Chemical Properties of Ambroxol HCl

Cas No. 23828-92-4 SDF
同義語 NA 872
Chemical Name 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride
Canonical SMILES C1CC(CCC1NCC2=CC(=CC(=C2N)Br)Br)O.Cl
Formula C13H18Br2N2O.HCl M.Wt 414.56
溶解度 ≥ 164.6mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Ambroxol HCl

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4122 mL 12.061 mL 24.122 mL
5 mM 0.4824 mL 2.4122 mL 4.8244 mL
10 mM 0.2412 mL 1.2061 mL 2.4122 mL
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In vivo Formulation Calculator (Clear solution) of Ambroxol HCl

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 9 reference(s) in Google Scholar.)

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