Amino-PEG11-amine |
| カタログ番号GC63930 |
2 つのモノジエチルスチルベストロール (DES) ベースのリガンドを結合するために使用される PEG ベース (12 ユニット) の PROTAC リンカーであるアミノ-PEG11-アミンは、乳がんの内分泌療法のためのより選択的で活性な ER アンタゴニストを調製するための代替戦略を提供します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 479200-82-3
Sample solution is provided at 25 µL, 10mM.
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Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15.
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