Amyloid-β (17-40) Peptide (human) (trifluoroacetate salt) (Synonyms: Aβ (17-40)) |
| カタログ番号GC42799 |
アミロイドβ（Aβ）（17-40）は、α-およびγシークレターゼによるアミロイド前駆体タンパク質（APP）の翻訳後処理によって形成されるAβタンパク質の24残基フラグメントです。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Amyloid-β (Aβ) (17-40) is a 24-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases. In vitro, Aβ (17-40) polymerizes into lattice-like structures that do not bind thioflavin T. It inhibits interactions between fibrinogen and biotinylated Aβ (1-42) as well as between cholesterol and apolipoprotein E (ApoE) with IC50 values of 13.4 and 25 μM, respectively. Aβ (17-40) increases the rate of Aβ (1-40) aggregation in vitro when used at an equimolar concentration. Aβ (17-40) (25 μM) induces cell death in cultured rat hippocampal neurons.
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