Anti-inflammatory agent 38 |
| カタログ番号GC70979 |
Anti-inflammatory agent 38(複合23 d)は要りNrf2 /伝達経路HO-1治療剤にIC50値0.38μMならノーだ
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Cas No.: 3032633-42-1
Sample solution is provided at 25 µL, 10mM.
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Anti-inflammatory agent 38 (compound 23d) (0.25, 0.5, 1 and 2 µM; 3 hours) can reduce ROS production in RAW264.7 cells stimulated with LPS (0.5 µg/mL LPS stimulates for 12 hours)[1].
Anti-inflammatory agent 38 (0.25, 0.5, 1 and 2 µM; 3 hours) significantly increases the expression of Nrf2 and HO-1 in LPS-stimulated RAW264.7 cells in a dose-dependent manner, and promoting LPS-induced Nrf2 nuclear translocation[1]
References:
[1]. Wang W, et al. Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities. Bioorg Med Chem.
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