Anti-SARS-CoV-2 Spike mAb (CR3022) (Synonyms: SARS-CR3022; SARS-CoV-2 Antibody-CR3022) |
カタログ番号GC60055 |
Anti-SARS-CoV-2 Spike mAb (CR3022) は、CHO 細胞由来のヒトモノクローナル IgG1 抗体です。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Anti-SARS-CoV-2 Spike mAb (CR3022) is a a CHO cell derived human monoclonal IgG1 antibody. It binds to both S1 domain of SARS-CoV/SARS-CoV-2 Spike protein[1][2].
CR3022 recognizes a cryptic epitope that is only accessible when S protein is in "open" conformations[1]. CR3022 binds more tightly to SARS-CoV because its epitope contains a glycan not present in SARS-CoV-2[2].
[1]. Yanling Wu, et al. Identification of Human Single-Domain Antibodies Against SARS-CoV-2. Cell Host Microbe. 2020 Jun 10;27(6):891-898.e5. [2]. Meng Yuan, et al. A Highly Conserved Cryptic Epitope in the Receptor Binding Domains of SARS-CoV-2 and SARS-CoV. Science. 2020 May 8;368(6491):630-633.
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(Based on Reviews and 31 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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