Antibacterial agent 131 |
| カタログ番号GC71202 |
Antibacterial agent 131 はキノリン誘導体である。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Antibacterial agent 131 (compound 4m) has antimicrobial activity with MIC90 values of 9.81 μg/mL for Escherichia coli ATCC 35218, E. coli ATCC 25922, Staphylococcus aureus ATCC 6538, and methicillin-resistant S. aureus (MRSA), respectively[1].
Antibacterial agent 131 has anti-candida effect with MIC90 values of ≤0.06, 0.24, 1.95, and 1.95 μg/mL for Candida krusei ATCC 6258, Candida parapsilosis ATCC 22019, Candida albicans ATCC 24433, and C. glabrata ATCC 90030, respectively[1].
Antibacterial agent 131 (24 h) has low cytotoxicity with an IC50 value of 34.51 μM in NIH/3T3 cells[1].
Antibacterial agent 131 (0.06-3.91 μg/mL) inhibits DNA-Gyrase Enzyme against E. coli[1].
Antibacterial agent 131 has antifungal activity via blocking ergosterol production[1].
References:
[1]. Asaf Evrim Evren, et al. Investigation of Novel Quinoline-Thiazole Derivatives as Antimicrobial Agents: In Vitro and In Silico Approaches. ACS Omega. 2022 Dec 29;8(1):1410-1429.
| Cas No. | SDF | ||
| Formula | C24H17ClN4OS | M.Wt | 444.94 |
| 溶解度 | DMSO : 62.5 mg/mL (140.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.2475 mL | 11.2375 mL | 22.4749 mL |
| 5 mM | 0.4495 mL | 2.2475 mL | 4.495 mL |
| 10 mM | 0.2247 mL | 1.1237 mL | 2.2475 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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