Apraclonidine (hydrochloride) (Synonyms: AL0 2145, ALO 2145) |
| カタログ番号GC42830 |
アプラクロニジン (塩酸塩) (ALO 2145) は、選択的な α2 および弱い α1 受容体アゴニスト活性であり、人間の眼の眼圧 (IOP) を効果的に低下させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 73218-79-8
Sample solution is provided at 25 µL, 10mM.
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Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine . It binds to α2-ARs in calf cortex, rat kidney, and rat spleen with IC50 values of 0.9, 4.3, and 4.2 nM, respectively. Apraclonidine also binds to α2-ARs in rat cerebral cortex, pig submandibular gland and lung tissue, and in dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively). It inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively). Opthalmic formulations containing apraclonidine have been used to treat elevated intraocular pressure.
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