Araguspongin B |
| カタログ番号GC40267 |
キセストスポンギンとアラグスポンギンは、最初に太平洋の海綿から単離された海洋天然物であり、血管拡張作用を持つことが知られています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 123000-02-2
Sample solution is provided at 25 µL, 10mM.
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Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties. Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores. Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 µM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
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