Arbutin-d4 (Synonyms: β-Arbutin-d4) |
カタログ番号GC48841 |
Arbutin-d4 は、Arbutin と標識された重水素です。アルブチン (β-アルブチン) はメラノサイトのチロシナーゼの競合的阻害剤であり、モノフェノラーゼの Kiapp 値は 1.42 mM です。ジフェノラーゼの場合は 0.9 mM。アルブチンは色素脱失剤としても使用されます。アルブチンは、ベアベリー植物 Arctostaphylos uvaursi から分離された天然のポリフェノールで、抗酸化、抗炎症、抗腫瘍特性を持っています。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Arbutin-d4 is intended for use as an internal standard for the quantification of arbutin by GC- or LC-MS. Arbutin is a glycosylated hydroquinone that has been found in Arctostaphylos plants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, and anti-inflammatory properties.1,2 It inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM).3 Arbutin (50 μM) inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes and inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts when used at concentrations greater than 125 μM.2 In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum.4 Formulations containing arbutin have been used in the treatment of hyperpigmentation disorders.
1.Seo, D.-H., Jung, J.-H., Lee, J.-E., et al.Biotechnological production of arbutins (α- and β-arbutins), skin-lightening agents, and their derivativesAppl. Microbiol. Biotechnol.95(6)1417-1425(2012) 2.Takebayashi, J., Ishii, R., Chen, J., et al.Reassessment of antioxidant activity of arbutin: Multifaceted evaluation using five antioxidant assay systemsFree Radic. Res.44(4)473-478(2010) 3.Maeda, K., and Fukuda, M.Arbutin: Mechanism of its depigmenting action in human melanocyte cultureJ. Pharmacol. Exp. Ther.276(2)765-769(1996) 4.Ye, J., Guan, M., Lu, Y., et al.Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-κBp65 pathwayPulm. Pharmacol. Ther.5453-59(2019)
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