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ARC19499 sodium

カタログ番号GC71242

ARC19499 sodium は、組織因子経路阻害剤(tfpi)を阻害するアプタマーであり、それによって、外部経路を介して血栓の開始と伝播を可能にする。

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ARC19499 sodium 化学構造

サイズ 価格 在庫数 個数
1 mg
$297.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

References:
[1]. Waters EK, Genga RM, Schwartz MC, et al. Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor.Blood. 2011;117(20):5514-5522.
[2]. Gissel M, Orfeo T, Foley JH, Butenas S. Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia.Thromb Res. 2012;130(6):948-955.

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