AST2818 mesylate (Synonyms: AST2818) |
| カタログ番号GC33096 |
アルフルチニブ (フルモネルチニブ) メシル酸塩は、EGFR の強力な阻害剤です。アルフルチニブ (フルモネルチニブ) メシル酸塩は、EGFR 活性変異および獲得耐性変異である T790M を阻害します。アルフルチニブ (フルモネルチニブ) メシル酸塩は、がん疾患、特に非小細胞肺がん (NSCLC) の研究に役立つ可能性があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2130958-55-1
Sample solution is provided at 25 µL, 10mM.
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AST2818 mesylate is an EGFR inhibitor.
AST2818 mesylate is designed to inhibit EGFR active mutations as well as the T790M acquired resistant mutation[1].
[1]. Y.Shi, et al. P2.03-028 Third Generation EGFR Inhibitor AST2818 (Alflutinib) in NSCLC Patients with EGFR T790M Mutation: A phase1/2 Multi-Center Clinical Trial. J Thorac Oncol. 2017 Nov, 12(11): S2138.
| Cas No. | 2130958-55-1 | SDF | |
| 同義語 | AST2818 | ||
| Canonical SMILES | C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(CCN(C)C)C)=O.CS(=O)(O)=O | ||
| Formula | C29H35F3N8O5S | M.Wt | 664.7 |
| 溶解度 | DMSO : 5 mg/mL (7.52 mM) | Storage | Store at -20°C,unstable in solution, ready to use. |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.5044 mL | 7.5222 mL | 15.0444 mL |
| 5 mM | 0.3009 mL | 1.5044 mL | 3.0089 mL |
| 10 mM | 0.1504 mL | 0.7522 mL | 1.5044 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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