ATR inhibitor 2 |
| カタログ番号GC39645 |
ATR 阻害剤 2 (VX-803) は、ATP 競合性、経口活性、選択的 ATR 阻害剤であり、Ki は <150 pM です。 ATR 阻害剤 2 は、8 nM の IC50 で ATR 駆動のリン酸化チェックポイント キナーゼ 1 (Chk1) リン酸化を強力に阻害します。抗腫瘍活性。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1613191-99-3
Sample solution is provided at 25 µL, 10mM.
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ATR inhibitor 2 is an ATP-competitive, orally active, selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2].
[1]. Frank T. Zenke, et al. Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy. Experimental and Molecular Therapeutics. [2]. Gorecki L, et al. Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy. Pharmacol Ther. 2020 Feb 26:107518.
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