AX 048 |
| カタログ番号GC42885 |
第IVAグループのリン脂質加水分解酵素A2（PLA2）は、カルシウム依存性細胞質型PLA2（cPLA2）として知られており、膜リン脂質からアラキドン酸を選択的に放出し、プロスタグランジンやロイコトリエンの合成を開始する上で中心的な役割を果たします。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 873079-69-7
Sample solution is provided at 25 µL, 10mM.
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The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes. AX 048 is a potent group IVA cPLA2 inhibitor that demonstrates 50% inhibition of the enzyme at a mole fraction (XI(50)) of 0.022. Pretreatment with AX 048 (ED50 = 1.2 mg/kg) dose-dependently reduces thermal hyperalgesia evoked by carrageenan injection of rat hind paw. At concentrations as high as 30 µM, AX 048 does not inhibit COX activity or interfere with central cannabinoid receptor signaling.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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