AXKO-0046 |
| カタログ番号GC65496 |
AXKO-0046 は、インドール誘導体で低分子の LDHB 選択的阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.
AXKO-0046 has selectivity and highly potent LDHB inhibitory activity with an value EC50 of 42 nM. AXKO-0046 bounds to the potential allosteric site away from the LDHB catalytic active site. AXKO-0046 can be used to validate LDHB associated pathways in cancer metabolism[1].
[1]. Sachio Shibata, et al. Identification of the first highly selective inhibitor of human lactate dehydrogenase B. Sci Rep. 2021 Nov 1;11(1):21353.
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