AZ506 |
| カタログ番号GC64124 |
AZ506 は、IC50 が 17 nM の強力な SMYD2 阻害剤です。 AZ506 は、細胞内の SMYD2 メチルトランスフェラーゼ活性を阻害し、SMYD2 を介したメチル化シグナルを減少させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2043321-54-4
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
AZ506 is a potent SMYD2 inhibitor with an IC50 of 17 nM. AZ506 inhibits SMYD2 methyltransferase activity in cells, leading to a decrease in the SMYD2-mediated methylation signal[1].
AZ506 inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with an EC50 of 1.2 μM. AZ506 inhibits SMYD2-mediated methylation (p53-me in U2OS cells) with an IC50 of 2.43 μM[1].
[1]. Cowen SD, et al. Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J Med Chem. 2016;59(24):11079-11097.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *