AZD-8418 (Synonyms: AZD-8418, AZD8418; AZD 8418;) |
| カタログ番号GB62285 |
AZD-8418は、ニコチンの摂取および求める行動を抑制するmGlu2受容体陽性アロステリック調節因子です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1198309-73-7
Sample solution is provided at 25 µL, 10mM.
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AZD-8418 is an mGlu2 receptor positive allosteric modulators that attenuates nicotine-taking and nicotine-seeking behavior. Acute treatment with AZD8418 (0.37, 1.12, 3.73, 7.46, and 14.92 mg/kg) and AZD8529 (1.75, 5.83, 17.5, and 58.3 mg/kg) deceased nicotine self-administration and had no effect on food-maintained responding. Chronic treatment with AZD8418 attenuated nicotine self-administration, but tolerance to this effect developed quickly. The inhibition of nicotine self-administration by chronic AZD8529 administration persisted throughout the 14 days of treatment. Chronic treatment with either PAMs inhibited food self-administration. AZD8418 (acute) and AZD8529 (acute and subchronic) blocked cue-induced reinstatement of nicotine- and food-seeking behavior.
Review for AZD-8418
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for AZD-8418
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