Bepotastine-d6 (besylate) (Synonyms: Bepotastine besilate-d6) |
カタログ番号GC91436 |
Bepotastine-d6は、GC-またはLC-MSによるbepotastineの定量化のための内部標準として使用することを目的としています。
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Cas No.: 2469626-71-7
Sample solution is provided at 25 µL, 10mM.
Bepotastine-d6 is intended for use as an internal standard for the quantification of bepotastine by GC- or LC-MS. Bepotastine is an antagonist of the histamine H1 receptor that is selective over H3, α1-, α2-, and β-adrenergic, dopamine D2long, serotonin 5-HT2, muscarinic acetylcholine, and benzodiazepine receptors.1 It reduces dye leakage from the nasal passages of rats acutely sensitized to an antigen (ED50 = 0.03 mg/kg) and inhibits histamine-induced bronchoconstriction in the anesthetized dog (ED50 = 3.2 µg/kg).2,3 Bepotastine prevents conjunctival vascular hyperpermeability in a guinea pig model of conjunctivitis in a dose-dependent manner.4 Formulations containing bepotastine have been used in the treatment of itching associated with allergic conjunctivitis.
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