BI-6C9 |
| カタログ番号GC41252 |
BI-6C9 は非常に特異的な BH3 相互作用ドメイン (Bid) 阻害剤であり、ミトコンドリア外膜電位 (MOMP) とミトコンドリア分裂を防ぎ、ミトコンドリアのアポトーシス誘導因子 (AIF) 放出とニューロンのカスパーゼ非依存性細胞死から細胞を保護します[ 1]。
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Cas No.: 791835-21-7
Sample solution is provided at 25 µL, 10mM.
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BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.
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