Biotin-PEG2-acid |
| カタログ番号GC62869 |
ビオチン-PEG2-酸は、抗体-薬物複合体 (ADC) の合成に使用される切断不可能な 2 ユニット PEG ADC リンカーです。
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Cas No.: 1365655-89-5
Sample solution is provided at 25 µL, 10mM.
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Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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