BMS 566419 |
| カタログ番号GC50180 |
BMS 566419 は、イノシン 5'-一リン酸デヒドロゲナーゼ (IMPDH) のアクリドンベースの阻害剤です。
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Cas No.: 566161-24-8
Sample solution is provided at 25 µL, 10mM.
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Potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.
Watterson et al (2007) Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 50 3730 PMID:17585753
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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