Boc-C1-PEG3-C4-OBn |
カタログ番号GC39350 |
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) は、PEG 組成を指す PROTAC リンカーです。 Boc-C1-PEG3-C4-OBn は、PROTAC SGK3 degrader-1 などの一連の PROTAC の合成に使用できます。 PROTAC には、リンカーで接続された 2 つの異なるリガンドが含まれています。 1 つは E3 ユビキチン リガーゼのリガンドで、もう 1 つは標的タンパク質のリガンドです。 PROTAC は、細胞内ユビキチン-プロテアソーム系を利用して、標的タンパク質を選択的に分解します。
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Cas No.: 2381196-81-0
Sample solution is provided at 25 µL, 10mM.
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTACDegrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.
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