BPK-29 |
| カタログ番号GC34502 |
BPK-29 は、C274 を共有結合で修飾することにより、非定型オーファン核受容体 NR0B1-タンパク質 (RBM45 や SNW1 など) の相互作用を破壊する特異的なリガンドです。 BPK-29 は、KEAP1 変異がん細胞の足場非依存性増殖を阻害します。
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Cas No.: 2143467-62-1
Sample solution is provided at 25 µL, 10mM.
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BPK-29 is a covalent small molecule that disrupts NR0B1 complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells[1].
BPK-29 substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1].
[1]. Woodruff TM,et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181(12):8727-34.
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