BPN-15606 |
| カタログ番号GC39566 |
BPN-15606 は、非常に強力な経口活性 γ-セクレターゼ モジュレーター (GSM) であり、SHSY5Y 神経芽細胞腫細胞による Aβ42 および Aβ40 の産生をそれぞれ 7 nM および 17 nM の IC50 値で減衰させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1914989-49-3
Sample solution is provided at 25 µL, 10mM.
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BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 significantly lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance[1].
[1]. Wagner SL, et al. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 Jul;362(1):31-44.
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