Brexpiprazole dihydrochloride - OPC 34712 dihydrochloride |
| カタログ番号GB40130 |
高親和性を持つ精神障害の臨床開発薬候補であり、h5-HT1A（部分作動薬）、h5-HT2A（拮抗剤）、hD2L（部分作動薬）、hα1B（拮抗剤）および hα2C-アドレナリン受容体（拮抗剤）に対してKi値が<1 nMです。Brexpiprazoleはまた、hD3、h5-HT2B、h5-HT7、 hα1A および hα1D アドレナリン受容体に対しても大きな親和性を示し(Ki <5 nM)、中程度の親和性を持ちます (Ki =19 nM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 913612-38-1
Sample solution is provided at 25 µL, 10mM.
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Drug candidate in clinical development for psychiatric disorders with high affinity for h5-HT1A (partial agonist), h5-HT2A (antagonist), hD2L (partial agonist), hα1B (antagonist) and hα2C-adrenergic (antagonist) receptors (Ki values <1 nM). Brexpiprazole also shows substantial affinity (Ki <5 nM) for hD3, h5-HT2B, h5-HT7, hα1A and hα1D adrenergic receptors, and moderate affinity for hH1 (Ki =19 nM).
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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