BW 246C (Synonyms: 8-epi BW 245C) |
| カタログ番号GC14859 |
DP受容体作動薬
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 65705-83-1
Sample solution is provided at 25 µL, 10mM.
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BW 246C is a DP receptor agonist.
The prostaglandin D2 (PGD2) receptors, members of G protein-coupled receptors, bind and are activated by prostaglandin D2. PGD2 receptors include the following proteins prostaglandin D2 receptor 1 (DP1) and prostaglandin D2 receptor 2 (DP2).
In vitro: BW 246C was found to be the less active C-8 diastereomer of the DP receptor agonist its analog BW 245C, having 70-fold less activity than that of BW 245C. For BW 245C, a significant species variation was observed in the anti-aggregatory potency so that it was about one hundred times more effective than in the human in the rat. However, the relative potencies of PGI2 and PGE1 were found to be similar in both species. Moreove, it was observed that in radioligand binding studies BW 245C had a high affinity and selectivity for PGD2 platelet receptors, and the binding to PGI2 or PGE2 receptors was not found [1].
In vivo: Animal study showed that, an intravenous bolus injection of 250 μg/kg BW 245C to spontaneously hypertensive rats was able to lower both systolic (-23%) and diastolic (-34%) blood pressure [1].
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Town, M. H.,Casals-Stenzel, J. and Schillinger, E. Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors. Prostaglandins 25, 13-28 (1983).
| Cas No. | 65705-83-1 | SDF | |
| 同義語 | 8-epi BW 245C | ||
| Chemical Name | (4R)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid | ||
| Canonical SMILES | [H]N(C(N(CCC(O)C1CCCCC1)[C@@H]2CCCCCCC(O)=O)=O)C2=O | ||
| Formula | C19H32N2O5 | M.Wt | 368.5 |
| 溶解度 | ≤50mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.7137 mL | 13.5685 mL | 27.137 mL |
| 5 mM | 0.5427 mL | 2.7137 mL | 5.4274 mL |
| 10 mM | 0.2714 mL | 1.3569 mL | 2.7137 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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