C18 Ganglioside GM1-d3 (d18:1/18:0-d3) (ammonium salt) (Synonyms: N-omega-CD3-Octadecanoyl monosialoganglioside GM1-d3, N-CD3-Stearoyl-GM, C18 GM1-d3, GM1 (18:1/18:0-d3), GM1 (d18:1/C18:0)-d3, Monosialoganglioside GM1-d3, N-Stearoyl Monosialoganglioside GM1-d3) |
カタログ番号GC46992 |
多様な生物学的活性を持つ神経ペプチド
Products are for research use only. Not for human use. We do not sell to patients.
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Sample solution is provided at 25 µL, 10mM.
C18 Ganglioside GM1-d3 (d18:1/18:0-d3) is intended for use as an internal standard for the quantification of C18 ganglioside GM1. Ganglioside GM1 is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2 C18 Ganglioside GM1 is found in the brain, primarily in the piriform cortex, amygdala nucleus, striatum, and hippocampal CA1 region.3 The ratio of C18 ganglioside GM1 (d20:1/18:0) to C18 ganglioside GM1 is decreased in the outer molecular layer of the hippocampal dentate gyrus in postmortem tissue from patients with Alzheimer's disease.4 [Matreya, LLC. Catalog No. 2050]
1.Kolter, T.Ganglioside biochemistryISRN Biochem.506160(2012) 2.Mocchetti, I.Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophinsCell Mol. Life Sci.62(19-20)2283-2294(2005) 3.Andres, A.D., Young, L.E.A., Gentry, M.S., et al.Spatial profiling of gangliosides in mouse brain by mass spectrometry imagingJ. Lipid Res.(2020) 4.Hirano-Sakamaki, W., Sugiyama, E., Hayasaka, T., et al.Alzheimer's disease is associated with disordered localization of ganglioside GM1 molecular species in the human dentate gyrusFEBS Lett.589(23)3611-3616(2015)
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