CAY10464 |
| カタログ番号GC43159 |
アリールヒドロカルボン受容体（AhR）は、リガンド依存性の細胞内転写因子であり、そのリガンドにはダイオキシン（TCDD、2,3,7,8-テトラクロロジベンゾジオキシン）、ベンゾ[a]ピレン、および煤塵粒子やコールタールからの多数のポリ芳香族炭化水素など、最も悪名高い異物質が含まれます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 688348-37-0
Sample solution is provided at 25 µL, 10mM.
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The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin (TCDD, 2,3,7,8-tetrachlorodibenzoparadioxin), benzo[a]pyrene, and numerous polyaromatic hydrocarbons from soot particles and coal tar. CAY10464 is a potent and selective AhR antagonist, with a Ki of 1.4 nM when tested in rabbit liver cytosol preparations. It is inactive as an estrogen receptor ligands even at 100 µM.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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