CCR6 inhibitor 1 |
| カタログ番号GC34521 |
CCR6 インヒビター 1 は強力かつ選択的な CCR6 インヒビターであり、サルおよびヒト CCR6 に対する IC50 は 0.45 および 6 nM であり、ヒト CCR1 (IC50、> 30000 nM) および CCR7 (IC50、9400 nM) よりも CCR6 ではるかに選択的です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2437547-04-9
Sample solution is provided at 25 µL, 10mM.
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CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1]. Moneky CCR6|0.45 nM (IC50)|Human CCR6|6 nM (IC50)|Human CCR7|9400 nM (IC50)
CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration[1].
[1]. Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072.
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