Cerestat (Synonyms: CNS 1102) |
| カタログ番号GC50060 |
セレスタット（セレスタット）は、神経保護効果を持つ非競合的NMDA受容体拮抗薬です。
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Cas No.: 137160-11-3
Sample solution is provided at 25 µL, 10mM.
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Potent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.
Reddy et al (1994) Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J.Med.Chem. 37 260 PMID:8295213 |Schäbitz et al (2000) The N-MthD.-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 31 1709 PMID:10884477
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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