Compound 115-7c (Synonyms: 4-(5-((Benzyloxycarbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid) |
| カタログ番号GB40151 |
化合物115-7c（908074-72-6）は、HSP70の人工共シャペロンとして機能します。化合物115-7cの活性は、ATPaseおよびタンパク質折り畳み活性を刺激するHSP40と同様です。tauを過剰発現する細胞株ではtauレベルを増加させます。ポリグルタミンの可溶化を誘導し、polyQによる毒性を悪化させます。化合物115-7cは、HSP70の機能理解に重要なプローブです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 908074-72-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70. The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau levels in cell lines overexpressing tau. Induces solubilization of polyglutamine and exacerbates polyQ-mediated toxicity. Compound 115-7c is an important probe for understanding HSP70 functions.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *