COX-2-IN-1 |
| カタログ番号GC31962 |
COX-2-IN-1 は、IC50 が 3.9 μM の強力で選択的な COX-2 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 787623-48-7
Sample solution is provided at 25 µL, 10mM.
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COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC50 of 3.9 μM.
COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC50s of >100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound[1].
[1]. Reddy MV, et al. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors. Bioorg Med Chem. 2008 Apr 1;16(7):3907-16.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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