CTP Synthetase-IN-1 |
カタログ番号GC71196 |
CTP Synthetase-IN-1 は、ヒトctps1とヒトctps2に対してic50sを32 nmと18 nmの経口活性を持つ強力なシチジン5'-三リン酸合成酵素(ctps)阻害剤である。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2338811-71-3
Sample solution is provided at 25 µL, 10mM.
CTP Synthetase-IN-1 (compound 27) inhibits rat CTPS1, rat CTPS2, mouse CTPS1, and mouse CTPS2 with IC50 values of 27 nM, 23 nM, 26 nM, and 33 nM, respectively[1].
CTP Synthetase-IN-1 (compound 27; 10-50 mg/kg; p.o; twice daily; for 18 days) shows significant pharmacological responses in collagen-induced arthritis (CIA) model[1].
References:
[1]. Andrew Novak, et al. Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation. J Med Chem. 2022 Dec 22;65(24):16640-16650.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *