Cyclobenzaprine-d6 (hydrochloride) (Synonyms: MK-130-d6) |
カタログ番号GC91384 |
シクロベンザプリン-d6は、GC-またはLC-MSによるシクロベンザプリンの定量のための内部標準として使用することを目的としています。
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Cas No.: 2748492-38-6
Sample solution is provided at 25 µL, 10mM.
Cyclobenzaprine-d6 is intended for use as an internal standard for the quantification of cyclobenzaprine by GC- or LC-MS. Cyclobenzaprine is a skeletal muscle relaxant.1,2,3 It is an antagonist of M1, M2, and M3 muscarinic acetylcholine receptors (mAChRs; Kis = 25, 60, and 6 nM, respectively), the histamine H1 receptor (IC50 = 20 nM), and serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2B, and 5-HT2C (Kis = 1,685, 330, and 56 nM, respectively). Cyclobenzaprine (1 mg/kg) prevents increases in the flexor reflex induced by the 5-HT2 receptor agonist DOI in spinalized rats.3 Formulations containing cyclobenzaprine have been used as muscle relaxants.
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