DA-3003-2 (Synonyms: NSC 663285) |
| カタログ番号GC41305 |
Cdc25二重特異性タンパク質チロシンホスファターゼは、細胞周期の進行に重要であり、しばしばがんで過剰発現しています。
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Cas No.: 383907-47-9
Sample solution is provided at 25 µL, 10mM.
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Cdc25 dual-specific protein tyrosine phosphatases are important for cell cycle progression and often overexpressed in cancers. Through the removal of inhibitory phosphates, they function to catalyze the activation of cyclin-Cdk complexes. DA-3003-2 is a Cdc25 phosphatase inhibitor (IC50 = 0.82 µM for human recombinant Cdc25B) that demonstrates antiproliferative activity. At 20 µM, it has been shown to arrest asynchronous PC-3 prostate cancer cells in G2/M phase.
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