DBCO-PEG5-NHS ester |
| カタログ番号GC66196 |
DBCO-PEG5-NHSエステルは、PROTACの合成に使用できるPEG/アルキル/エーテルベースのPROTACリンカーです。 DBCO-PEG5-NHS エステルは、抗体薬物複合体 (ADC) の合成に使用される切断可能な ADC リンカーです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2144395-59-3
Sample solution is provided at 25 µL, 10mM.
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DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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