DDO-5936 |
| カタログ番号GC62305 |
DDO-5936 は、強力で特異的な Hsp90-Cdc37 PPI 阻害剤です。 DDO-5936 は、結腸直腸癌の研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2355377-13-6
Sample solution is provided at 25 µL, 10mM.
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DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer[1].
DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47[1].
DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group[1].DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency[1].
[1]. Wang L, et al. Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer. J Med Chem. 2020;63(3):1281-1297.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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