Dibenzoyl Thiamine (Bentiamine) |
| カタログ番号GC30576 |
チアミンの誘導体であるジベンゾイルチアミン（ベンチアミン）（ベンチアミン）は、体内に急速に吸収され、チアミンに変換されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 299-88-7
Sample solution is provided at 25 µL, 10mM.
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Dibenzoyl Thiamine (Bentiamine), a derivative of thiamine, is rapidly absorbed into the body and converted to thiamine.
Dibenzoyl Thiamine is a thiol-type thiamine composed of thiamine and benzoic acid. It is not decomposed by aneurinase (thiamine-decomposing enzyme), making it more suitable for food processing than thiamine hydrochloride[1].
A chronic toxicity study in male Wistar rats for 6 months at dietary levels of up to 1000 ppm, shows Dibenzoyl Thiamine to be without specific toxic effects. A teratogenicity study in rats show Dibenzoyl Thiamine to be without embryotoxic or teratogenic effects. Tests for mutagenicity in bacterial systems, in the dominant lethal assay and in an in vivo cytogenetics test show Dibenzoyl Thiamine to be without mutagenic. Dibenzoyl Thiamine is metabolised to Vitamin Br and benzoic acid, and the benzoic acid moiety is almost quantitatively excreted in the urine, as hippuric acid[1].
[1]. Heywood R, et al. Tumorigenic and toxic effect of O,S-dibenzoyl thiamine hydrochloride in prolonged dietaryadministration to rats. Toxicol Lett. 1985 Jul;26(1):53-8.
Animal experiment: | Rats: Groups of 65 male and 65 female Sprague-Dawley rats are fed diets containing Dibenzoyl Thiamine at levels of 1000 ppm (Group 1) and 10000 ppm (Group 2). A third group is fed a control diet. The animals are assigned by computer to groups on the basis of body weight, such that mean body weights in all groups are approximately equal. 10 Animals from each group are killed at 52 weeks, the remaining animals at week 105. All signs of ill-health or reaction to treatment are recorded daily. The animals are weighed at weekly intervals[1]. |
References: [1]. Heywood R, et al. Tumorigenic and toxic effect of O,S-dibenzoyl thiamine hydrochloride in prolonged dietaryadministration to rats. Toxicol Lett. 1985 Jul;26(1):53-8. | |
| Cas No. | 299-88-7 | SDF | |
| Canonical SMILES | O=C(C1=CC=CC=C1)S/C(CCOC(C2=CC=CC=C2)=O)=C(N(CC3=CN=C(C)N=C3N)C=O)/C | ||
| Formula | C26H26N4O4S | M.Wt | 490.57 |
| 溶解度 | DMSO : 50 mg/mL (101.92 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0384 mL | 10.1922 mL | 20.3845 mL |
| 5 mM | 0.4077 mL | 2.0384 mL | 4.0769 mL |
| 10 mM | 0.2038 mL | 1.0192 mL | 2.0384 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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