Difopein TFA |
| カタログ番号GC64375 |
14-3-3 タンパク質 (高度に保存された真核生物調節分子) の特異的かつ競合的な阻害剤であるジフォペイン (TFA) は、14-3-3 が標的タンパク質に結合する能力をブロックし、14-3-3/リガンド相互作用を阻害します。 . Difopein (TFA) はアポトーシスの誘導を引き起こし、シスプラチンの細胞を殺す能力を高めます。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells[1].
[1]. Masters SC, et al. 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem. 2001 Nov 30;276(48):45193-200. Epub 2001 Sep 27.
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