Diprotin A TFA (Ile-Pro-Pro (TFA)) (Synonyms: Ile-Pro-Ile TFA) |
| カタログ番号GC31414 |
ジプロチン A TFA (Ile-Pro-Pro (TFA)) (Ile-Pro-Ile TFA) は、ジペプチジルペプチダーゼ IV (DPP-IV) の阻害剤です。
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Cas No.: 209248-71-5
Sample solution is provided at 25 µL, 10mM.
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Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1].
In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1].
[1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.
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