DL-Sulforaphane Glutathione (Synonyms: SFN-glutathione, SFN-GSH, Sulforaphane-GSH) |
| カタログ番号GC52368 |
スルフォラファンの代謝物
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Cas No.: 289711-21-3
Sample solution is provided at 25 µL, 10mM.
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DL-Sulforaphane glutathione is a metabolite of the class I and II histone deacetylase (HDAC) inhibitor and anticancer agent sulforaphane .1 It increases mRNA expression of the genes encoding glutathione S-transferase A1 (GSTA1) and the UDP-glucuronosyltransferase (UGT) isoform UGT1A1 in HepG2 cells when used at a concentration of 15 µM.2
1.Wang, H., Khor, T.O., Yang, Q., et al.Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytesMol. Pharmacol.9(10)2819-2827(2012) 2.Basten, G.P., Bao, Y., and Williamson, G.Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cellsCarcinogenesis23(8)1399-1404(2002)
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