DL-Sulforaphane N-acetyl-L-cysteine (Synonyms: SFNNAC) |
| カタログ番号GC43493 |
Nrf2の抗酸化応答エレメント（ARE）への活性化は、酸化的および/または電気的ストレスに対する細胞保護遺伝子発現に中心的な役割を果たします。
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Cas No.: 334829-66-2
Sample solution is provided at 25 µL, 10mM.
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Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major metabolite of SFN , a powerful inducer of chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression. At 75 µM, SFN-NAC has been shown to increase ARE expression in HepG2-C8 cells. Its reported potency on ARE-related gene expression is roughly 8-fold less than SFN.
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